Unraveling Mouse Glioma Heterogeneity with Dce-t1 Mri and 1h-csi Metabolome Pattern Perturbation
نویسندگان
چکیده
R. V. Simões, M. L. García-Martín, T. Delgado-Goñi, S. Lope-Piedrafita, and C. Arús Bioquímica i Biologia Molecular, Universitat Autònoma de Barcelona, Cerdanyola del Vallès, Barcelona, Spain, Bioquímica, Universidade de Coimbra, Coimbra, Coimbra, Portugal, Resonancia Magnética, Clínica Nuestra Señora del Rosario, Madrid, Spain, CIBER-BBN, Cerdanyola del Vallès, Spain, Servei de Resonància Magnètica Nuclear, Universitat Autònoma de Barcelona, Cerdanyola del Vallès, Spain
منابع مشابه
Assessment of mouse glioma vasculature using SPIO and small molecule contrast agents: sequential implementation of alternate perfusion MRI methodologies
M. M. Pike, C. P. Langford, C. D. Neumann, L. B. Nabors, G. Y. Gillespie Medicine, University of Alabama at Birmingham, Birmingham, AL, United States, Surgery, University of Alabama at Birmingham, Birmingham, AL, United States, Neurology, University of Alabama at Birmingham, Birmingham, AL, United States Prognosis remains extremely poor for glioblastoma multiforme (GBM), the most common of the ...
متن کاملSpiral Perfusion Imaging With Consecutive Echoes (SPICE™) for the Simultaneous Mapping of DSC- and DCE-MRI Parameters in Brain Tumor Patients: Theory and Initial Feasibility
Dynamic contrast-enhanced (DCE) and dynamic susceptibility contrast (DSC) magnetic resonance imaging (MRI) are the perfusion imaging techniques most frequently used to probe the angiogenic character of brain neoplasms. With these methods, T1- and T2/T2*-weighted imaging sequences are used to image the distribution of gadolinium (Gd)-based contrast agents. However, it is well known that Gd exhib...
متن کاملSimutaneous measurement of pharmacokinetic model parameters and T1/B1 using Active Contrast Encoding MRI
Introduction: T1-weighted dynamic contrast enhanced magnetic resonance imaging (DCE-MRI) has been widely used to probe tumor microenvironment using kinetic model parameters, such as transfer constant K, extra cellular space volume fraction ve, and vascular space volume fraction vp. Accurate estimation of these kinetic parameters requires B1-corrected T1 values [1]. However, it is not trivial to...
متن کاملI-41: Imaging Strategy for Diagnosis of Adnexal Masses Including US,CT Scan and MRI
Adnexal masses are spectrum of diseases from benign non neoplastic and neoplastic masses to malignant neoplasms. Endovaginal ultrasonography (US) is the fisrt and invaluable modality for assessment of adnexal masses because it is available and has a high negative predictive value. Important morphologic features are solid (vascularized) tissue, vascular and thick septations, and papillary projec...
متن کاملCan Dynamic Contrast-Enhanced Magnetic Resonance Imaging Combined with Texture Analysis Differentiate Malignant Glioneuronal Tumors from Other Glioblastoma?
An interesting approach has been proposed to differentiate malignant glioneuronal tumors (MGNTs) as a subclass of the WHO grade III and IV malignant gliomas. MGNT histologically resemble any WHO grade III or IV glioma but have a different biological behavior, presenting a survival twice longer as WHO glioblastomas and a lower occurrence of metastases. However, neurofilament protein immunostaini...
متن کامل